The Eradication Of Cancer And Cancer Essay - 1118 Words

1.1. Introduction Eradication of cancer is one of the key challenges for medicine in the 21st century, breast cancer being the most common type of cancer in women, worldwide (Arteaga and Baselga, 2012, Vidal et al., 2012 and Weinstein et al., 1997).Breast cancers are classified on the basis of expression of hormone receptors i.e., Estrogen receptor, Progesterone receptor and HER2. The subtypes are as follows: †¢ Luminal tumors (HR +) †¢ HER2 amplified tumors †¢ Triple negative breast cancer tumors (TNBC) Approximately, 10-15% of breast cancer cases are accounted by triple negative breast cancer. These tumors are characterized by the absence of ER, PR and HER2. Chemotherapy, therefore, is the only systemic option for patients with TNBC. (Twelves C et al, 2016 and Banerji et al.,2012) 1.2. Comparison of 2D and 3D (spheroid) cancer models on the basis of their drug screening ability Several studies have shown the use of 2D cancer models to identify the efficacy of a particular drug. However, these cancer models have limited predictive value to show a realistic stimulation of in vivo tumor microenvironment. This is due to large differences in physiological conditions as well as morphology between 2D cancer models and in vivo tumors. Factors such as therapy resistance, drug transport and binding, cell invasion and migration of tumors cannot be effectively studied in vitro with the use of these cancer models. Hence, selecting a clinically active drug is a challenging task when 2DShow MoreRelatedTobaccos Harmful Effects, Health and Economic Essay1334 Words   |  6 Pagesand Malaria combined, according to International Union Against Cancer. This addicting drug can in fact end up giving the user a death sentence. As the body grows older, the DNA atoms can be mutated by this seemingly harmless plant. This mutation of cells can eventually spread and the user will end up with a body full of cancer. 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With the discovery of the BRCA1( BReast Cancer gene one) and BRCA2 (BReast Cancer gene two) genes, breast cancer can be detected with a great amount of certainty on a genetic level in some women and men. 40,000 women and men die of breast cancer each year. Knowing this it is very important to try to detect the mutation

Unit 7 †Childcare and Education Level 3 Cache Free Essays

string(107) " of information from agencies outside the settingwhich may contribute to the assessment of learning needs\." E1 Collate evidence which describes the role of the practitioner in meeting children’s learning needs. Gather and present information about the role of the practitioner whenchildren’s learning needs. A practitioner’s role in meeting children’s learning needs are to understand and work with each and every child’s learning needs. We will write a custom essay sample on Unit 7 – Childcare and Education Level 3 Cache or any similar topic only for you Order Now They can do this by providing different opportunities to individual children because each child is unique and learns differently. The practitioners’ role would therefore be to plan and resource an environment that is challenging and helps children learn in many different areas of their learning. The UN Convention on the Rights of the Child is there for the rights of children should allow children priority as they are more venerable. It states that all children’s wants and learning needs should be met. The UN Convention on the Rights of the Child has 4 cores principles and they are: Non-discrimination regardless of race, sex, gender, religion, disability and any other reason (Article 2), the best interest of the child for example; prevent child from being separated from their families unless separate on is necessary for the best interest of the child, the right to live, survival and development, freedom of speech and thought etc†¦ Article 11, 14 ; 13). Another thing as a practitioner, we need to do is promote a positive environment for parents, colleges and the children because a positive environment can mean that everyone within the setting can get a positive outcome in order to help meet the child’s needs best. Having on-going training can also benefit th e practitioners role in meeting children’s needs, teach them about childcare and can help them meet the child’s learning needs because the practitioners go on training outside the setting to get a better insight on how to work with different practitioners, adults and children. E2 Provide information about current influences on play +E4 Include examples of different theoretical models of how children play and learn. One theorist which currently influences children’s play is Jean Piaget (1948). His theory was a theory on Cognitive development. He believed that children develop in stages and that they progress through these stages in chronological order. Piaget (1948) said that there were 4 stages of development from birth to adulthood; serisori: motor- birth – 2 years, pre-operational: 2-7 years, concrete operational: 7-11/12 years, formal operations: 11/12-16 years old. He carried out a study which is called ‘mountain study’ to investigate further into his theory. This study was done in a group of children being arranged in front of a simple plaster mountain range and than he sat himself to the side and asked the children to pick from four pictures. This study showed that older children picked what Piaget (1948) saw and the younger children would pick the view they could see. When looking back at this study, Piaget (1948) found out that the older children tend to understand other peoples views. The practitioners would have a role within the Early Years setting to support the children through the different stages of development and the adults should work alongside one another to help the child develop. His theory of cognitive development is based on the importance of active discovery learning where children have child-centred classroom (Maureen D 2006). Piaget theory (1948) allows practitioners to have opportunities to learn without teaching them, appropriate activates are set up through observing the child and these activities are than suitably challenging with real experiences (Maureen D 2006). ’the balance between adult-directed play and child-initiated play should be tipped heavily in favour of child-initiative play. ’’ (Maureen D 2006). Another theorist which currently influences children’s play is Susan Isaacs (1930). She was a psychoanalyst who believed that free play indoors and outdoors is important for children’s needs, developmen t as well as helping them to learn better. She said that free play was important and necessary for children. In 1924 Susan Isaacs became the principle of Malting house, where she set up an educational experiment alongside Geoffrey Pkye(1942) to experiment with different teaching ideas on a small group of children aged two and a half to seven years. Inside the house were three interesting features; the use and development of language to promote thinking, the attention paid to children’s emotions needs and the emphasising on animosity and finding out. Piaget (1948) and Sigmund Freud (1988) were both influenced by Susan Isaacs’s (1930) theory. This theory allows children to understand what is being asked and gives the children challenge in answering a question where they can think on their own. E3- Provide information about current influences on the planning and provision Gather information about what currently influences planning and provision of learning opportunities. Every Child Matters Framework which is currently in the process to be changed is part of the Children Act 2004; it is a piece of legislation which has and influences planning and provisions of learning opportunities. The Every Child Matters ensures that settings provide quality of children’s and young people’s play and learning. This supports children from birth to 19 years. When practitioners plan, they should relate their work to the five outcomes for children; be healthy, stay safe, enjoy and achieve though learning, make a positive contribution to society and achieve economic well-being. OFSTED is a regulatory body which makes sure all childcare settings are carrying out correct planning and allowing the children to learn. This is done by having inspections which are based on the five outcomes of Every Child Matters framework. They also do this by looking at each childcare setting to see what curriculum is being offered. Each childcare setting’s curriculum will be varied and this is something the OFSTED will understand for example: every child care setting will follow the (EYFS, 2012) Early Years Foundation Stage but if a setting has children of the age of 6they would follow the National Curriculum. OFSTED requires that practitioners and workers are familiar with the relevant curriculum and requirements of OFSTED. E6 Include TWO (2) examples of information from agencies outside the settingwhich may contribute to the assessment of learning needs. You read "Unit 7 – Childcare and Education Level 3 Cache" in category "Papers" School Nurse A school nurse provides a variety of services such as undertaking health interviews and administering immunisation programmes. They can be employed by the local health authority, community trust, primary care trust or by the school directly. The responsibility of a nurse would include these roles: * Providing confidential health advice for individual children * Assessing the whole need of the school community and develop a health plan including a policy on bulling * Promoting good parenting skills by helping and supporting parents * Co-ordinating immunisation programmes Health plans for children with any disability * Providing training for school-based staff to support children with healthcare needs e. g. : asthma * Giving advice to parents, carers or school staff on childhood illnesses and the management and control of infection in the disease * Drug and alcohol abuse and smoking * Sexual health and relationship for example pregnancy * Exercise and healthy eating * Ment al health and wellbeing * Obesity * Eating disorder * Disabilities E7 Include TWO (2) plans for curriculum activities which show different approaches to planning learning opportunities E8 Include information about the importance of consulting with parents and others when planning and providing learning opportunities. It is important to consult with parents and others when planning and providing learning opportunities for the child because the parents know their child’s best interests. This is because parents are their first educators and they know what resources their child likes to use and the likes and dislike of the child. It is also important because parents you may need permission from parents in order to carry out a certain activity. Effective partnership between a childcare setting and parents will help the environment of the setting become more positive for both the child and parents using the provision. It will make the setting and parents understand each other better as well as benefit the child because the child will feel safe and want to learn and achieve better. E9 Provide evidence of current and relevant research throughout the portfolio. Evidence of current and relevant research is provided in my appendix at the end of my assignment. D1 Include an explanation of the key issues in recording assessments. D2 Include an explanation of the key issues in recording assessments. + C2 Analyse the role of assessment in informing planning and respecting learning needs. There are many important points to consider when recording assessments of children. The most important issue in recording assessments would knowing the different techniques available to use and find the one that suits most when recording the assessment of the child. These techniques maybe; written narrative, video, photographs, target child observation, checklist observation, tick charts, time sampling, event sampling and mapping to record assessments of the children. The practitioner would need to decide what type of technique would be appropriate in assessing the child and the activity carried out. When using one of the techniques the practitioner would need to check if it was reliable and valid. A technique would be good when the practitioner is able to monitor the child’s behaviour, progress and development as well as keeping them frequent and up to date. Another important factor to consider when recording assessments of children is confidentiality. C1 Analyse the importance of planning and providing learning opportunities to meet children’s diverse needs. In order to plan and provide learning opportunities to meet children’s diverse needs practitioners need to make sure that all children are included within the task and activity. This can be done by providing a large range if motivating opportunities which are accessible to all children to help them develop and allow to support them. Another thing would be a safe environment for children to learn in which is free from any discrimination and bullying. This can be done by valuing and respecting one another (children, teachers, parents and other professionals). The practitioners would be working with other professionals such as an occupational therapist to help the child have the best learning opportunities available. B1 Evaluate how the current influences on play and different theoretical models affect the planning and provision of learning opportunities. Jean Piaget’s theory influenced today’s practice as†¦ Susan Isaac’s theory influenced today’s practice as she believed that play is very important and relives freedom which allows settings to have child lead activities. Another thing she influenced was the parents and carers of the children because she showed and made practitioners aware of the fact that parents are seen as the child’s first educators and therefore they are the most important when providing learning opportunities for the child. Susan’s theory is based on working with parents and carers and this is very vital to today’s influences on play in settings which than allows practitioners to be able to plan learning opportunities for the children in their care. This can also affect planning because the practitioners may not be interacting with the children very well because they are having child lead activities and the practitioners are not experiencing what the parents and cares say about the child and how they act during the activities toward the practitioners. Research has shown thatyoung children learn best when they are actively interacting with others†¦Ã¢â‚¬ ¦. E Wood and N Bennett (1999) International Journal ofEarly Years Education 7 (1) 5-16. This affects planning because†¦Ã¢â‚¬ ¦. Discussion might also consider whether models are appropriate for all settings and factors which might be barriers to implementing change This affects planning because†¦Ã¢â‚¬ ¦. A Include a reflective account of the role of the practitioner in supporting the learning needs of children Develop the information gathered for E1 and use your experiences to consider learning needs of children and show understanding of your practice in supporting the learning needs of children. Use this reflection to suggest appropriate ways you could develop your role as a practitioner when working with children. My role as a practitioner in meeting children’s learning needs are to respect and value each individual child’s learning needs as well as understanding them. This will than allow me to provide different opportunities to individual children because ach child has individual needs and wants in the way that they learn by. Another role of mine is to plan for stimulating activities which are high in challenge to allow them to develop and learn new skills and abilities. Having a challenging environment for children allows the children to extend their learning in various styles and ways. The Equal opportunity policy is also taken into consideration by all practitioners in the setting so that all children are treated equally with respect and can enjoy and achieve their full potential. Staff ratio is also taken into account because we need enough staff in a setting to avoid accidents and keep all children safe and in a secure environment Bibliography: Books: Tassoni. Penny, Kate. Beith, Kath. Bulum and Harriet. Eldridge (2007) CACHE level 3 Child Care and Education 4th edition, London: Heinemann Marian. Beaver, Jo. Brewster, Sandy. Green, Sally. Neaum, Heidi. Sheppard, Jill. Tullack and Miranda. Walker (2008) Childcare and education Cache level 3 Cheltenham: Nelson Thorns How to cite Unit 7 – Childcare and Education Level 3 Cache, Papers

Pnin Review Essay Example

Pnin Review Paper Essay on Pnin Hapless, droll and touching ironic professor, who teaches Russian language in a small private university. This is Timofey Pnin the hero of the novel by Vladimir Nabokov A long time since I held in my hands the works of classical literature.. Perhaps that is why it was quite difficult to get used to long, flowery sentences. But the main character with a funny name Pnin subdued immediately. For some reason I always wanted to feel sorry for him, and even protect against all, do not let fall into the web of intrigue, which are weaved around him at the university. It seemed to me that just as it relates to the author himself. Â « He (Pnin) was perhaps too cautious, too wary of tricky pitfalls feared too painful as it would be strange surroundings (unpredictable America) is not pulled him into some ridiculous story. Pnin was not scattered, and the world, and Pnin had to put things in order there. I was so fascinated by the novel about the adventures of an expat in the vast New World, he did not even notice that it was morning. I then smiled and sadness together with Pnina. I reveled in the beauty of the language. And in the morning it was over. For me and for Pnina. It is hardly necessary to tell, than all these adventures have ended for Timofey Pavlovich. Well, I have left a pleasant aftertaste. Like what happens from chocolates donated by someone else. In modern books it is rare to find such a rich language that delights. Do you want to remember all of the unusual comparison like a book a gift for the bibliophile. Although, of course, this is just my humble opinion. For example, my mother can not read the works of Vladimir Nabokov. But it is impossible to please all women. A book is really very good! We will write a custom essay sample on Pnin Review specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Pnin Review specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Pnin Review specifically for you FOR ONLY $16.38 $13.9/page Hire Writer

Advice for Drama Teachers - Rehearsal Activities

Advice for Drama Teachers - Rehearsal Activities Recently, we received a message in our Plays/Drama forum. We thought we would share it with you because it touches upon an issue many directors and drama teachers deal with. Here it is: I am currently working on my major production that my drama class is putting on at the end of next month. There are 17 students in the cast, but obviously some have bigger parts than others. Any suggestions for what I can get those with smaller parts to do while they are not on stage? They are really struggling with just watching the rehearsals (when not involved), and since its a class, I feel I should be making them do something, since they are also getting a credit for the course. Im just not sure how to make the best use of these students. Whenever youre directing youth theater, many of the children will smaller roles. Therefore, youll have to make certain those children dont waste their time during rehearsals. Your goal should be not just to put on a great show, but to make certain all  performers (no matter how small the part) improve their acting and their knowledge of the theatrical arts. If you find yourself in a similar situation, then yours is a challenging problem that many teachers and youth theater directors face. If this were a professional production, you would be able to focus your attention on the principal actors. However, as an instructor, you want all of your performers to have a positive educational experience. Lets explore some ideas for  making  the most out of your rehearsals. Choose Plays to Fit The Cast Size This first rule is simple - but its important. If you know that you will be directing a cast of twenty or more kids, make certain that you dont choose a play where only three characters have lines and the rest are lingering in the background. Some family-themed shows such as Annie or Oliver have a lot of kids in one or two scenes, and thats it. The rest of the show focuses on only a handful of characters. Therefore, look for scripts that offer a lot of little but juicy roles in addition to the lead characters. Background Extras Enhance the Setting Lets assume it is too late to pick another script. What then? Go through the play and find all of the scenes in which actors can liven up the background. Are there any crowd scenes? Are there scenes that take place in a park? A senior center? A courtroom? On film sets, there is an assistant director (AD), with one of the primary jobs of the AD being to place the background extras - actors who may simply walk across the scene or play a part in the crowd. With that introduction, before you watch an AD in action, you might figure it to be a simple job. But while  watching an experienced AD work youll realize that theres an artistry to directing background. Characters in the background can help to establish the setting and the energy of the play. If your show has a large cast with several crowd scenes, make the most of it. Create a whole world on the stage. Even if the young actors dont have a single line, they can convey a character and enhance the play. Create Character Outlines No matter how big or small the role, every young actor can benefit from character outlines. If you are directing the principals and the ensemble cast members have some downtime, ask them to write about their characters. Ask them to respond to some of these prompts: Describe your characters personality.What thoughts are going through your characters mind?What goals and dreams does your character have?What worries or frightens your character?Describe your characters most embarrassing moment.Describe your characters greatest triumph. If time allows, the cast members could develop scenes (either written or improvisational) showing these not-so-minor characters in action. And if you have any students that enjoy reading and writing, teach them more about creative ways to analyze plays to get more out of the experience and possibly influence them to write their own work. Practice Scene Work If the students/actors have a lot of downtime during rehearsal, give them sample scenes from other plays to work on. This will allow them to learn more about the diverse world of theater, and it will help them become more versatile performers. Also, this is an easy way for them to sharpen their acting skills in order to land a larger role in the next production. Toward the end of rehearsal, make certain you set aside time for the students to perform their scene work to the rest of the cast. If you are able to do this consistently, the students with the smaller roles will still be able to get a great deal of acting experience - and those who observe the scenes will get a taste of the classic and contemporary pieces you present. Improv! Improv! Improv! Yes, whenever the cast is down in the dumps, cheer up your young performers with a quick improvisation exercise. Its a great way to warm up before rehearsal, or a fun way to wrap things up. For more ideas, check out our list of improv activities. Behind the Scenes Oftentimes students sign up for a drama class as an elective, and even though they love the theater, they arent yet comfortable being in the spotlight. (Or maybe they just arent ready yet.) In that case, teach the participants about the technical aspects of theater. They could spend their free time during rehearsals learning lighting design, assistant directing, sound effects, costumes, prop management, and marketing strategies. But however you involve your young actors, make certain you are giving them creative work - NOT busy work. Give them projects that will challenge them artistically and intellectually. And, above all, show them through example how fun the theater can be.

Using the Spanish Preposition Tras

Using the Spanish Preposition 'Tras' The Spanish preposition tras, usually meaning behind or after, isnt a particularly common preposition. In fact, you could probably get by without even using it at all, as the prepositional phrases detrs de (behind in location) and despuà ©s de (after in time) can usually be used instead. Tras is more common in writing than in speech. Even so, tras has significant use in journalese (its a shorter word to use in headlines) and in a few phrases such as uno tras otro (one after the other) and dà ­a tras dà ­a (day after day). Here are the most common meanings of tras, along with examples of its use. Tras Meaning After (In Time) Tras is sometimes used to mean after (in time), as in the following examples: Se degradà ³ la libertad de prensa tras la eleccià ³n. (Freedom of the press was diminished after the election.) El restaurante abre de nuevo tras ser cerrado. (The restaurant is opening again after being closed.) Tras Meaning In Pursuit Of Tras can also mean after (in the sense of advancing toward or being in pursuit of), as in these cases: Iba  tras  las riquezas.  (He was after riches.)   El perro salià ³Ã‚  tras  ella.  (The dog went after her.) Tras Meaning Behind It can also be used to say behind (in location), as in these examples: Tras las puertas cerradas puede haber violencia. (Behind closed doors there can be violence.) Necesita contraseà ±a para participar en las conversaciones tras la pared de proteccià ³n corporativa. (You need a password in order to participate in conversations behind the corporate firewall.) Tras- as a Prefix Tras- also is commonly used as a prefix, where it is a shortened form of trans- and often the equivalent of the English prefix trans-, as in  trascendental (transcendental), trascribir (to transcribe), trascontinental (transcontinental).

Article response paper Example | Topics and Well Written Essays - 750 words - 3

Response paper - Article Example The problems of the ESL students are mainly at the sentence level. Their writing problems are different as compared to the students of native speakers. It begins at the word and sentence levels. They face difficulties in every component of the sentence, and with spelling, grammar and word usage. The essential difference between the native speakers and ESL students is that the former can speak English correctly, as such they can also write correctly. The latter have skills in their native language. They have ideas but their issues relate to the use of appropriate words and grammatical errors confront them. Personal observations/comments On close examination of the article, I realized the importance of the rater and the challenges the ESL students have to face in reading or writing in English. They have problems in several segments of life, and racial segregation overrides all other considerations. Low self-efficacy, financial difficulties, separation from immediate family members and friends, highly different cultural environment, all these contribute to the problems related to assimilation in the mainstream society. Student behavior in classroom in America differs much and the discipline is loose. They can come late to the class, question teachers, cut jokes and this type of behavior is not accepted in the Chines classrooms. Their main difficulties are in the areas of form, morphology, terminology and syntax which vary from their native language. They may have ideas but lack expression; as such the audience may not be able to follow the contents. The difficulties for acquisition of skills in writing differ for various cultural groups of ESL students. Before reading the article I used to consider the problem of the ESL student’s writing in isolation. On the strength of the various issues mentioned in the article, I now realize that it is but one of the multifarious problems faced by the student and the improved ability of the student in writing may addres s to partial solution of some of those issues. ESL students are a heterogeneous lot. Much difference exists even when the students are from the same country as they belong to different States/Regions, where slang, tradition and culture differ. With such varied cultural and linguistic backgrounds the assessment of their English writing is beset with problems. Some sort of reconciliation will have to be worked out to arrive at an authentic solution, as it concerns the career of the combustible younger generation. In a competitive job market, each mark, each recommendation counts. So, the rater may build or break the career of an ESL student, unintentionally though, with the deficient system of rating. The author is aware of this complexity and has mentioned twenty reviews and given details of those empirical studies as for the factors affecting rating of ESL writing in North American school contexts, segregating them as rater-related and task-related and has highlighted their importan t components. These factors are not exclusive and research on the subject is a continual process and the author has informed that in the light of the experience gained, gaps and proposed directions for future research have been identified. The author emphasizes a number of times in the article that assessment of writing is the problematic area for which no cut and dry formula cannot be submitted as the final word on the subject. He quotes Speck and Jones (1998), â€Å"there are more problems than solutions -problems of inter-grader

Manage IT Security for the London Olympic 2012 games Essay

Manage IT Security for the London Olympic 2012 games - Essay Example A safety and security strategy and security measures have been set up to respond to these. According to BBC News (2011), 13,500 armed forces personnel and 10,000 police officers will be deployed during the Olympics to enforce security. This will be backed by 50 marine officers in fast response boats who will be joined by 100 military personnel (Seida 2012). The structure of the safety and security strategy has been built around strategic objectives and each of these be will be delivered though a special programme headed by a programme manager. The Protect Programme will ensure the safety and security of games sites, infrastructure and venues, and people involved in the Games. The Programme will also consider protecting people travelling to the Games. The Prepare Programme will provide specialist response by ensuring that the necessary contingencies and workforce are in place to manage events that could significantly compromise or disrupt the security of the Games. The Identify and Di srupt Programme will provide the required capacity and capability to identify and disrupt all forms of threats to the Games. Command, Control, Plan and Resource (C2PR) programmes will ensure that required resources are available and can be deployed to the necessary sites to provide safety and security (Home Office 2012). One of the assumptions for this strategy is that the greatest security threat will be terrorism. Despite the above security, the potential IT security vulnerabilities of the event are still high and the major threat is identity theft. Vacca (2003) defines this as a type of crime where someone steals the identity of someone else and poses as that person. This is basically an identify fraud. In true-name ID fraud, the person’s identify information is not modified. Terrorists are also likely to stealing key pieces information from people like driver’s license numbers and social security numbers and combine them with fake information to create new identiti es which they will use to gain entry into the games venues. This is called synthetic ID fraud as noted by McFadden (2010). Criminals could pose as fans, players, visitors and even London Organising Committee for the Olympic Games (LOCOG) officials. Once they gain entry into the venues, they commit terrorist attacks. They can also use these IDs to obtain goods and services. ID theft is a form of cyber crime. Giles (2010) explains that hackers access personal information of other people online. To get this information, the terrorists could send messages posing as the official website for LOCOG, trying to sell tickets. As people respond, they get their personal details and use them to make fake IDs. ID theft could also result from phishing attacks like man-in-the-middle phishing. This is where a criminal positions themselves between the legitimate site and the user (Emigh and Labs 2005). In this way, they will save valuable information from different sources and send false messages bet ween LOCOG and its users. To detect this, LOCOG will have to setup a spoof-reporting email address that users will send mails to. This will provide